Graham R. Moran

Photo of G.R. Moran

Biochemistry
Associate Professor
PhD, University of New England, Australia
(414) 229-5031
e-mail: moran@uwm.edu
The Moran Research Group Page
Research Description

Recent Publications

12. K. Johnson-Winters, V. M. Purpero, M. Kavana, T. Nelson, and G. R. Moran (2003) (4-Hydroxyphenyl)pyruvate Dioxygenase from Streptomyces avermitilis : The Basis for Ordered Substrate Addition. Biochemistry, 42, 2072-2080.

13. M. Kavana and G. R. Moran  (2003) The Interaction of (4-Hydroxyphenyl)pyruvate Dioxygenase with the Specific Inhibitor 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione. Biochemistry, 42, 10238-10245.

14. A. Amaya, K. Brzezinski, N. Farrington, and G. R. Moran (2004) Preliminary Kinetic Analysis of Human Homogentisate 1,2 Dioxygenase. Archives of Biochemistry and Biophysics 421, 135-142.

15. M. Neidig, M. L. Kavana, G. R. Moran, and E. I. Solomon (2004) CD and MCD Studies of the Non-Heme Ferrous Active Site in (4-Hydroxyphenyl)pyruvate Dioxygenase: Correlation Between Oxygen Activation in the Extradiol and alpha-KG Dependent Dioxygenases. J. Am. Chem. Soc., 126, 4486-4487.

16. J. Brownlee, K. Johnson-Winters,  D. H. T. Harrison and G. R. Moran (2004) The Structure of the Ferrous Form of (4–Hydroxyphenyl)pyruvate Dioxygenase from Streptomyces avermitilis in Complex with the Therapeutic Herbicide, NTBC. Biochemistry, 43, 6370-6377.

17. G. R. Moran (2005) (4–Hydroxyphenyl)pyruvate Dioxygenase. Archives of Biochemistry and Biophysics. (special issue, invited reviews) 433(1):117-28.

18. K. Johnson-Winters, V. Purpero and G. R. Moran (2005) The Accumulation of Multiple Intermediates in the Catalytic Cycle of 4-(Hydroxyphenyl)pyruvate Dioxygenase from Streptomyces avermitilis. Biochemistry, 44, 7189 – 7719.

19.  Michael L. Neidig, Andrea Decker, Michael Kavana, Graham R. Moran and Edward I. Solomon (2006) Spectroscopic and computational studies of NTBC bound to the non-heme iron enzyme (4-hydroxyphenyl)pyruvate dioxygenase: Active site contributions to drug inhibition. Biochemical and Biophysical Research Communications, 338, 206-214.

20. Vincent M. Purpero and Graham R. Moran.(2006) Catalytic, Non-Catalytic and Inhibitory Phenomena: Kinetic Analysis of (4-Hydroxyphenyl)pyruvate Dioxygenase from Arabidopsis thaliana. Biochemistry, 45, 6044 – 6055.

21. Michael L. Neidig, Andrea Decker, Oliver W. Choroba, Fanglu Huang, Michael Kavana, Graham R. Moran, Jonathan B. Spencer and Edward I. Solomon. (2006) Spectroscopic and Electronic Structure Studies of Non-Heme Iron Enzymes: Aromatic Electrophilic Attack vs. H-atom Abstraction. PNAS, in press.

22. Michael L. Neidig, Christina D. Brown, Michael Kavana, Oliver W. Choroba, Jonathan B. Spencer, Graham R. Moran and Edward I. Solomon. (2006) Spectroscopic and Electronic Structure Studies of the Role of Active Site Interactions in the Decarboxylation Reaction ofa-Keto Acid-Dependent Dioxygenases. Journal of Inorganic Biochemistry,100, 2108-2116.

23. Karen R. Crozier and Graham R. Moran (2007) Heterologous Expression and Purification of Kynurenine-3-monooxygenase from Pseudomonas fluorescensstrain 17400. Protein Expression and Purification,51, 324-333.

24. Vincent M. Purpero and Graham R. Moran. (2007) The Diverse and Pervasive Chemistries of the –Keto Acid Dependent Enzymes. Journal of Biological Inorganic Chemistry 12, 587-601.

25. John A. Conrad and Graham R. Moran. (2008) The Interaction of Hydroxymandelate Synthase with 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. Inorganica Chimica Acta., 361, 1197-1201

26. Karen E. Keith, Lauren Killip, Panqing He, Graham R. Moran and Miguel A. Valvano. (2007) Burkholderia cenocepacia C5424 Produces a Pigment with Antioxidant Properties Using a Homogentisate Intermediate. Journal of Bacteriology, 189, 9057-9065

27. June Brownlee, Panqing He, Graham R. Moran, and David H. T. Harrison (2008) Two Roads Diverged: The Structure of Hydroxymandelate Synthase from Amycolatopsis orientalis in Complex with 4-Hydroxmandelate. Biochemistry, 47, 2002-2013

See the complete list here.
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