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October 2007 Meeting
6:00 PM - Social Hour Dinner - (Prices include tax and gratuity) Details to follow Members/Guests – $20.00 For dinner reservations, please call subject="ACS Dinner Reservation"
ABSTRACTAmphotericin B represents a potential prototype for small molecules with the capacity to perform protein ion channel-like functions in the context of living systems. Efforts to harness this potential and/or improve the notoriously poor therapeutic index of this clinically vital antifungal agent would benefit from a molecular level understanding of this channel-like activity. We have recently developed a simple, efficient, and modular strategy for making small molecules in a manner analogous to peptide synthesis, i.e., via the iterative cross-coupling of B-protected haloboronic acid building blocks. This talk will summarize our progress towards the iterative cross-coupling-based total synthesis of amphotericin B and a series of its derivatives collectively designed to systematically probe the poorly understood channel-like activity of this remarkable natural product.BIOGRAPHICAL SKETCH:Marty Burke completed his undergraduate studies in chemistry at Johns Hopkins University in 1998. He then moved to Boston where he obtained a Ph.D. in organic chemistry at Harvard University as a Howard Hughes Predoctoral Fellow and an M.D. at Harvard Medical School as an NIH Fellow in the Medical Scientist Training Program. In 2005, he joined the faculty in the Department of Chemistry at the University of Illinois at Urbana-Champaign, where he is currently an Assistant Professor. His research focuses on the synthesis and study of small molecules with protein-like functions.
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| HTML by: John Picione - jpicione@uwm.edu - February 6 , 2007 | ||||||
