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NOVEMBER 2006 Meeting
For dinner reservations, please call
Joe Piatt at Carroll College
e-mail: firstname.lastname@example.org subject="ACS Dinner Reservation"
All are welcome.
Come and hear the speaker without attending the dinner.
Bleomycin (Blm) is an unusually large and complex antibiotic with significant clinical anti-cancer properties. The molecule has several functional domains, including a broadly reactive metal binding region that is tethered by a peptide to a DNA intercalation/binding region and a disaccharide unit with ill-defined function. Its cellular activity depends on site-selective, DNA double-strand cleavage. An inquiry into Blm's cellular properties demonstrates the requirement for Fe, its limited accumulation by the nucleus, and probable activation of Fe(III)Blm by cytochrome P450 reductase. Our chemical model studies have been based on the pioneering work of Peisach that showed Fe(III)Blm was reductively activated to HOO-Fe(III)Blm. We have used Co analogs as robust models for understanding the structure-reactivity relations among FeBlm species.
David H. Petering is University Distinguished Professor of Chemistry and Biochemistry at the University of Wisconsin-Milwaukee, where he began his career in 1971. He graduated from Wabash College with a B.A. and from the Department of Biological Chemistry at the University of Michigan with a Ph.D., working with Graham Palmer on iron-sulfur protein chemistry.
Since 1987 Dr. Petering has served as Director of the National Institute of Environmental Health Sciences Marine and Freshwater Biomedical Sciences Center at UW-Milwaukee. The Center's mission is to develop and utilize aquatic animal models in environmental health research; members have been instrumental in adapting the zebrafish model for vertebrate development for developmental toxicology studies. This past year the Center and scientists in the Children's Research Institute of Children's Hospital of Wisconsin have merged to form the Children's Environmental Health Institute, with Petering as Co-director. Finally, in 2002 Petering became director of the new UWM Institute of Environmental Health and in that capacity has helped to develop young investigators in environmental health at UWM and to link environmental health science to Hmong, Latino, and Native American communities.
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