Milwaukee Section - American Chemical Society the amalgamator

October 2000 Meeting

Fluorous Synthesis Techniques: From Separating Mixtures to Making Mixtures Dennis P. Curran Distinguished Service Professor Bayer Professor of Chemistry University of Pittsburgh

Thursday, October 19, 2000 Alumni Memorial Union Marquette University

DIRECTIONS

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6:00 PM	- Social Hour - Room 227
7:00 PM	- Dinner - Room 227
8:00 PM	- Program - Weasler Auditorium

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Buffet Dinner: (Prices include tax and gratuity) Chicken Breast with Pommery Mustard Sauce. Beef Tips in Burgundy Wine Sauce. Herb Roasted New Potatoes. Tossed Garden Salad. Seasonal Fresh Fruit Salad. Chef's Seasonal Fresh Vegetables. Rolls and butter. Assorted Cakes and Pies. Coffee, Tea, or Milk.

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Members/Guests	....	$18.00
Chemistry Students	....	$9.00

Make Dinner Reservations by
Friday, October 13, 2000
Call Bruce Warren at
Marquette University - 288-3515
9491chem@marquette.edu
Please indicate the names of those attending and if any are students
All are welcome.
Come and hear the speaker without attending the dinner.

Fluorous-tagged molecules can be separated from non-tagged molecules by solid phase extraction over fluorous reverse phase silica gel. This technique is ideal for solution phase parallel synthesis because it allows simple yet substantive separations of organic reaction mixtures. Because it separates primarily by fluorine content, fluorous reverse phase silica gel can also be used in a chromatographic mode to separate fluorous molecules from each other. This separation forms the basis of new mixture synthesis techniques in which members of a series of substrates are tagged with different fluorous tags, mixed, carried through a series of reactions, and then separated based on the tag prior to detagging. These fluorous techniques are the first mixture techniques that are amenable to solution phase synthesis yet still allow for both the separation and identification of the final products of the mixture.

Dennis P. Curran received his B.S. in 1975 from Boston College. His PhD was granted from the University of Rochester in 1979 where he worked under Professor Andrew S. Kende. After a two year postdoctoral stay with Professor Barry M. Trost at the University of Wisconsin-Madison, Dr. Curran joined the faculty of the Chemistry Department at the University of Pittsburgh in 1981. He now holds the ranks of Distinguished Service Professor and Bayer Professor of Chemistry, and is the American Editor of Tetrahedron: Asymmetry and Tetrahedron Letters. Among other awards, Dr. Curran has received the American Chemical Society Award for Creativity in Organic Synthesis (2000) and the Cope Scholar Award (1988), and the Janssen Prize for Creativity in Organic Synthesis (1998).. He is currently the Chairman of the ACS Division of Organic Chemistry and an Alexander Humbolt Research Fellow. Dr. Curran has authored over 200 papers, six patents and one book. He is well known for his work at the interface of radical chemistry and organic synthesis and more recently he has made significant contributions to the emerging discipline of fluorous chemistry.